Tópicos em Biologia Tumoral

Ementa: O câncer apresenta-se como importante problema de saúde pública, exibindo elevada morbidade e mortalidade em todo o mundo. Em paralelo, o conhecimento da biologia do processo cresce exponencialmente nas últimas décadas, em particular atrelado ao avanço da biologia molecular. Nesse contexto, a disciplina aborda elementos relevantes da biologia tumoral, dentro de um enfoque celular e molecular, destacando-se os seguintes pontos:

• Conceito, classificação, diferenças entre neoplasias benignas e malignas;
• Circuitaria molecular no câncer: ciclo celular, proliferação e diferenciação celular;
• Imuno-histoquímica: princípios e aplicações;
• Tumores transplantáveis;
• Genética molecular do câncer: instabilidade cromossômica e mutações, oncogenes, genes supressores de tumores;
• Microambiente tumoral; estroma e invasão;
• Vasculogênese tumoral (contexto molecular, padrões de organização, marcadores e quantificação),
• Marcadores prognósticos em oncologia;
• Inflamação, imunidade e imunoterapia no câncer: aspectos críticos.

Bibliografia:

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DASGUPTA et al. Cancer’s Achilles’ Heel: Apoptosis and Necroptosis to the Rescue. International Journal of Molecular Sciences. v. 18: p. 23, 2017.
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HAO et al. TGF-_- Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. International Journal of Molecular Sciences, v. 20, p. 2767, 2019.
LECARPENTIER et al. Multiple Targets of the Canonical WNT/b-Catenin Signaling in Cancers, Frontiers in Oncology, v. 9, p. 1548, 2019.
LIU et al. Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis. Molecular Cancer. v. 16, p. 176, 2017.
MUCAJ, V.; SHAY, JES.; SIMON, MC. Effects of hypoxia and HIFs on cancer metabolism. International Journal of Hematology, v. 95, p. 464-470, 2012.
PIETRAS, K.; OSTMAN, A. Hallmarks of cancer: interactions with the tumor stroma. Experimental Cell Research, v. 316, p. 1324-1331, 2010.
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REDDY, BY.; LIM, PK.; SILVERIO, K.; PATEL, AS.; WON, BW.; RAMESHWAR, P. The microenvironment effect in the progression, metastasis and dormancy of breast cancer: a model system within bone marrow. International Journal of Breast Cancer, 2012, 7 p.
SAMPIERI, K.; FODDE, R. Cancer stem cells and metastasis. Seminars in Cancer Biology, v. 22, p. 187-193, 2012.
SHIBUE, T.; WEINBERG, RA. Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Seminars in Cancer Biology, v. 21, p. 99-106, 2011.
SLEEMAN, JP.; CHRISTOFORI, G.; FODDE, R.; COLLARD, JG.; BERX, G.; DECRAENE, C.; RUEGG, C. Concepts of metastasis in flux: the stromal progression model, Seminars in Cancer Biology, v. 22, p. 174-186, 2012.
TAFANI, M.; PUCCI, B.; RUSSO, A.; SCHITO, L.; PELLEGRINI, L.; PERRONE, GA.; VILLANOVA, L.; SALVATORI, L.; RAVENNA, L.; PETRANGELI, E.; RUSSO, MA. Modulators of HIF1 and NFkB in cancer treatment: is it a rational approach for controlling malignant progression? Frontiers in Pharmacology, v. 4, 2013, 13 p.
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YAZIJI H, BARRY T. Diagnostic immunohistochemistry:what can go wrong? Advances in Anatomic Pathology, v. 13, p. 238-246, 2006.
YI, S; HAO, Y; NAN, K; FAN, T. Cancer stem cell niche: a target for novel cancer therapeutics. Cancer Treatments Reviews, v. 39, p. 290-296, 2013.