Tópicos em Biologia Tumoral

Topics on Tumor Biology

Syllabus

Approach to relevant elements of tumor biology, with cellular and molecular emphasis, highlighting aspects related to neoplastic cells, tumor microenvironment, and the host’s response, in association with the main methods to investigate such events. Molecular Circuitry in cancer: cell cycle, cell proliferation, and differentiation. Immuno-histochemistry: principles and applications, antigen recovery, and amplification systems. Molecular genetics of cancer: chromosome instability and mutations, oncogenes, tumor-suppressing genes, epigenetic events. Stroma and tumor invasion: tumor vasculogenesis (molecular context, organization patterns, markers, and quantification), MEC and cancer, hypoxia and tumor progression. Inflammation, macrophages, dendritic cells, natural-killer cells and cancer. Cancer as a systemic disease / metastasis.

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